Palmitoyl Hexapeptide-52
Encapsulated and delivered directly to where it's needed, helping to visibly smooth the look of expression lines and wrinkles without a single needle.
Peptide Pro Resilience® Serum Concentrate
30ml · Lasts around 4 weeks
Softens · Calms · Rebalances
TARGETS:
Expression lines · Redness · Stressed skin · Dehydration · Barrier
The power of five serums in one.
Powered by encapsulated, drone-delivered peptides, this multi-award-winning serum helps visibly soften lines and wrinkles, calm reactive skin and repair the skin barrier for a calmer, smoother and plumper complexion.
Clinically proven to improve skin cell repair by 42.6% in 24 hours (in vitro).*
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The Sachi Skin Promise
We’re confident in our formulations and we want you to feel the same before you commit.
Try an eligible Sachi Skin formula consistently for 30 days. If you do not notice a difference in your skin, you may be covered by our 30-Day Results Guarantee. Eligibility and terms apply*.
- Smooths the look of lines and wrinkles
- Provides lasting hydration for a smoother, plumper complexion
- Calms visible reactivity and irritation
- Restores balance to overwhelmed skin
- Strengthens and supports the skin barrier
- Supports skin recovery and regeneration
- Suitable for post-treatment, post-retinoid skin & pregnancy safe
"Over the years, I have layered different serums, to support skin strength, smooth expression lines and promote plumpness, whilst also trying to prevent sensitivity and reactiveness my skin experiences over winter. I quickly realised how I was overloading my skin and damaging the skin barrier.
When creating Peptide Pro Resilience® Serum Concentrate, I wanted to combine several existing serums into one. I focused on antioxidants, peptides, anti-redness, repair, barrier, anti-acne and post-suncare altogether in an oil-free formulation, to boost skin resilience in one simple but incredibly intelligent step." - Farah
A lightweight, gentle yet powerful formula driven by encapsulated, drone-delivered peptides, an advanced delivery system designed to target deeper layers for enhanced efficacy and support targeted skin repair where it is needed most.
At its core, this is a multi-pathway resilience system combining a targeted peptide delivery system with a 10.5% Ayurvedic Bioflavonoid Complex, a concentrated blend of antioxidant-rich botanicals traditionally used to calm, restore and strengthen skin.
Paired with CM Beta Glucan Technology and 5 multi-molecular hydrators, it works to repair, soothe, hydrate and reinforce the skin barrier while improving resilience over time.
This integrated approach helps restore balance to sensitised, reactive or post-treatment skin, including after retinoid use, supporting recovery when your skin needs it most.
- After cleansing, use 1-2 pumps on the face, neck and chest.
- Use twice daily AM & PM to ensure optimal delivery of peptides and key ingredients.
- Allow the treatment to fully absorb into the skin before proceeding to your next step.
- Layer before Vitamin C, retinoids, or other serums, following the “thinnest to thickest” rule.
- Use in conjunction with and before Future Veil® Firm & Repair Peptide Cream for enhanced hydration and to support skin resilience, firmness, and smoothness.
- Use around the eye area on crows feet, before eye creams.
- Use over lips that show signs of collagen loss.
- Massage deeply into frown lines.
Layer beneath - LED devices and post laser treatments to support recovery and repair.
- Refrigerate for an instant cooling, depuffing boost.
Complete your ritual
Peptide Pro Resilience® Serum Concentrate - 30ml is Step II · Restore. Add the steps that come before and after it.
Your Longevity Ritual
Four clinical steps. Each one prepares skin for the next.
$281.60
$352
Save $70.40
Clinical study notes +
* Based on an in-vitro study on human keratinocytes (skin cells).
** Based on an independent clinical study conducted on 20 male and female volunteers aged 35–70 with visible signs of ageing and redness-prone skin.
** The product was applied twice daily for 56 days with no changes to existing skincare routines.
** Clinical evaluations were conducted at baseline, 28 days, and 56 days using Visia-CRP-5 Primos technology, self-assessment questionnaires, and dermatological supervision.
** No adverse skin or ocular reactions were observed, confirming skin compatibility and acceptability.
** All photos are original and have not been edited, retouched, or digitally altered.
For diverse skin tones
Clinically proven
Cruelty-free
Dermatologist tested
Eco-conscious
8-week consumer trial results
0
%
saw smoother lines and wrinkles*
0
%
felt firmer, more lifted skin*
0
%
noticed dark spots and uneven tone visibly improved*
Real customer results
Real relief for sensitive skin
“Pro Resilience Serum is Elite! ... after 5 minutes of using the serum my skin is calmer, and the redness are gone.” - Lola
Skin starting to look more even
“Noticeable difference, a new staple in my routine! I noticed reduced redness and skin tone/texture improvement in 6 weeks!” - Amy
Key Ingredients
Palmitoyl Hexapeptide-18
The precision targeting peptide that works in synergy with Hexapeptide-52, together delivering a visibly smoother and firmer-looking skin.
CM Beta Glucan
A powerhouse humectant that attracts and locks in moisture whilst visibly supporting a calmer, more resilient-looking skin.
Hyaluronic Acid & Tamarind
Together they deliver deep, lasting moisture for a visibly plumper and more supple-looking skin.
Glycerin & Aloe Vera
Draw moisture to the surface whilst visibly calm and soothe, helping skin look and feel more comfortable.
Turmeric, Liquorice Root & Knotweed
Powerful brighteners that work together to visibly fade the appearance of dark spots and uneven skin tone.
Arnica & Cucumber
Known for their soothing properties, helping to visibly calm the look of redness and support comfortable-feeling skin.
Milk Thistle & Thyme
Antioxidant-rich botanicals that help defend against the look of UV-induced dullness and daily environmental stress.
Centella Asiatica (Gotu Kola)
Visibly soothe the look of redness whilst supporting a firmer, more supple-looking skin.
Ceramides
The building blocks of a healthy-looking skin barrier. Help visibly restore the appearance of a smooth, resilient skin.
Phytosphingosine
A naturally occurring skin-identical lipid that helps support the appearance of a balanced, healthy-looking skin.
Vegan Cholesterol
A plant-derived skin-identical lipid that works alongside ceramides to help maintain the appearance of a smooth and well-protected skin.
Rosmarinyl Glucoside
A stabilised, bioavailable form of rosemary antioxidant that helps protect against environmental damage for a more resilient-looking skin.
Caffeyl Glucoside
A stabilised form of caffeic acid (a potent antioxidant) that helps visibly support a calmer, more even-looking skin tone whilst defending against environmental stressors.
Gallyl Glucoside
A stabilised form of gallic acid delivering antioxidant support to help skin look visibly soothed and more balanced.
Palmitoyl Hexapeptide-52
Encapsulated and delivered directly to where it's needed, helping to visibly smooth the look of expression lines and wrinkles without a single needle.
Palmitoyl Hexapeptide-18
The precision targeting peptide that works in synergy with Hexapeptide-52, together delivering a visibly smoother and firmer-looking skin.
CM Beta Glucan
A powerhouse humectant that attracts and locks in moisture whilst visibly supporting a calmer, more resilient-looking skin.
Hyaluronic Acid & Tamarind
Together they deliver deep, lasting moisture for a visibly plumper and more supple-looking skin.
Glycerin & Aloe Vera
Draw moisture to the surface whilst visibly calm and soothe, helping skin look and feel more comfortable.
Turmeric, Liquorice Root & Knotweed
Powerful brighteners that work together to visibly fade the appearance of dark spots and uneven skin tone.
Arnica & Cucumber
Known for their soothing properties, helping to visibly calm the look of redness and support comfortable-feeling skin.
Milk Thistle & Thyme
Antioxidant-rich botanicals that help defend against the look of UV-induced dullness and daily environmental stress.
Centella Asiatica (Gotu Kola)
Visibly soothe the look of redness whilst supporting a firmer, more supple-looking skin.
Ceramides
The building blocks of a healthy-looking skin barrier. Help visibly restore the appearance of a smooth, resilient skin.
Phytosphingosine
A naturally occurring skin-identical lipid that helps support the appearance of a balanced, healthy-looking skin.
Vegan Cholesterol
A plant-derived skin-identical lipid that works alongside ceramides to help maintain the appearance of a smooth and well-protected skin.
Rosmarinyl Glucoside
A stabilised, bioavailable form of rosemary antioxidant that helps protect against environmental damage for a more resilient-looking skin.
Caffeyl Glucoside
A stabilised form of caffeic acid (a potent antioxidant) that helps visibly support a calmer, more even-looking skin tone whilst defending against environmental stressors.
Gallyl Glucoside
A stabilised form of gallic acid delivering antioxidant support to help skin look visibly soothed and more balanced.
View full ingredient list
Listed in descending order of concentration (INCI)
Aqua/Water/Eau, Glycerin, Panthenol, Propanediol, Pentylene Glycol, Sodium Carboxymethyl Betaglucan, Polygonum Aviculare (Knotweed) Extract, Rosmarinyl Glucoside, Caffeyl Glucoside, Gallyl Glucoside, Palmitoyl Hexapetide-52, Palmitoyl Hexapetide-18, Sodium Hyaluronate, Tamarindus Indica (Tamarind) Seed Extract, Ceramide NP, Ceramide AP, Phytosphingosine, Ceramide EOP, Arnica Montana (Arnica) Flower Extract, Curcuma Longa (Turmeric) Root Extract, Silybum Marianum (Milk Thistle) Seed Extract, Thymus Vulgaris (Thyme) Leaf Extract, Aloe Barbadensis Leaf Juice Powder, Sodium Anisate, Centella Asiatica (Asiatic Pennywort) Extract, Citric Acid, Glycyrrhiza Glabra (Licorice) Root Extract*, Cucumis Sativus (Cucumber) Fruit Extract*, Sodium Lauroyl Lactyate, Sodium Benzoate, Leuconostoc/Radish Root Ferment Filtrate, Butylene Glycol, Phenoxyethanol, Sodium Levulinate, Xanthan Gum, Potassium Sorbate, Aphanothece Sacrum Polysaccharide, Cholesterol, Carbomer, Ethylhexylglycerin, Polyvinyl Alcohol, Latic Acid/Glycolic Acid Copolymer *(Certified Organic)
The Technology
The Technology
A targeted action approach to promote firmness and smooth the appearance of contraction lines. Peptides help firm and smooth skin, but only if they reach the right cells. Acting as intelligent carriers, our microscopic “drones” safeguard the actives in the serum as they travel through the skin before releasing them exactly where they can perform at their highest potential. This advanced targeting technology enhances peptide stability and bioavailability, allowing the formula to deliver visible firming and reparative benefits with exceptional efficiency and minimal irritation.
What the Experts Noticed
“The Peptide Pro Resilience Serum from Sachi Skin is an all-time favorite for both me and my clients at home and in clinic.”
Jolie De FeisLicensed Esthetician
"The serum is exactly what was missing from the barrier repair products currently available. It's an elegant lightweight formula that visibly calms the skin and restores plumpness. Results over buzzwords with this one!"
Dr Piotr JanickiDermatologist
“Thoroughly impressed by the smart and thoughtful product formulations that work WITH the skin instead of forcing it to change.”
Dr Tego Kirnon-JackmanOwner of clinic SkinMenu, Aesthetic doctor
Serum First. Moisturiser Second.
Targeted serum care, followed by multi-corrective, multi-restorative moisture.
Restore
Peptide Pro Resilience® Serum Concentrate
A lightweight serum that softens the look of expression lines, supports barrier strength and delivers sustained hydration, helping sensitised skin feel calmer and more resilient.
Strengthen
Future Veil® Firm & Repair Peptide Cream
A multi-corrective longevity cream that replenishes plumpness and supports firmness, elasticity and the moisture barrier for fuller, smoother, stronger-looking skin over time.
Frequently Asked Questions
Within 24 hrs: Skin instantly feels hydrated, plumper and calm.
Within 1-2 weeks: Skin will feel more hydrated; post-sun skin will feel calmer, and reactive skin conditions will feel soothed. Skin will look healthier and more radiant.
Within 2-8 weeks: Skin will feel less reactive, and texture will appear smoother and visibly more balanced.
Within 12 weeks+: Over time, the powerful fusion of antioxidants and peptides will continue to support skin firmness, elasticity, collagen and repair, helping to reduce the appearance of fine lines and wrinkles.
Peptide Pro Resilience® Serum Concentrate is a lightweight serum that targets contraction lines, supports skin’s resilience to internal and external stressors, delivering intense hydration whilst calming redness. It layers and synchronises with our Future Veil™ Peptide Cream to support firmness, smoothen fine lines, and maintain a healthy skin state.
You will want to layer the serum first followed by the peptide cream to support, hydrate, firm and protect.
Peptide Pro Resilience® Serum Concentrate can help with reddened and post blemish skins to support skin recovery and repair, thanks to Arnica Extract, which can help to support skin capillary and strength. Please note, PIE is a vascular skin concern and can take some time to resolve. We suggest pairing Peptide Pro Resilience® Serum Concentrate with Triphala Pigmentation Corrector for optimum results.
Rosacea is a medical skin condition and we always recommend that you speak with your doctor first. However, Peptide Pro Resilience® Serum Concentrate can help to relieve some of the symptoms and redness associated with rosacea, for visibly calmer and more even skin.
Yes. Peptide Pro Resilience® Serum Concentrate is an excellent post-sun skincare step, formulated to help support the skin barrier, replenish hydration, and soothe visible redness caused by environmental stressors such as UV exposure. For optimal recovery, apply after Saponins Cream Cleanser and follow with Future Veil® Peptide Cream to lock in hydration and support skin repair.
While Peptide Pro Resilience® doesn’t directly alter GLP-1 pathways, it does address many of the visible skin changes associated with GLP-. It's peptide complex, CM-β-glucan, and dermal-strengthening actives support collagen integrity, improve firmness, boost resilience, and enhance the skin’s ability to repair helping counter the tired, slack, or quickly “deflated” look some experience on GLP-1 medications.
Yes! The serum is safe to use, but always consult your doctor for personal advice if concerned.
A luxurious, lightweight fluid emulsion. It has no artificial fragrance.
